Which of the following is a first-line treatment for pelvic inflammatory disease (PID)?

First-line treatment for pelvic inflammatory disease (PID) primarily consists of antibiotic therapy. PID is an infection of the female reproductive organs that can result from sexually transmitted infections or other bacterial infections. The use of antibiotics is essential to effectively eradicate the organisms responsible for the infection and to prevent long-term complications, such as infertility or chronic pelvic pain.

Common regimens for treating PID often include a combination of antibiotics that target Neisseria gonorrhoeae and Chlamydia trachomatis, which are frequently implicated in the condition. These regimens can vary based on the severity of the disease and the clinical setting, but the key takeaway is the essential role of antibiotic therapy in treating PID.

The other options provided, such as Metronidazole and Ciprofloxacin, while potentially useful in certain scenarios or as part of broader treatment regimens, do not constitute first-line monotherapy specifically for PID. Goldenseal extract is not a recognized treatment for PID and lacks evidence of efficacy for this condition. Therefore, highlighting the importance of antibiotic therapy as a cornerstone in managing PID underscores its critical role in addressing the infection effectively.