When a Pap smear reveals atypical glandular cells (AGUS), what is the most appropriate intervention?

When a Pap smear reveals atypical glandular cells (AGUS), the most appropriate intervention is colposcopy and endometrial sampling. AGUS can indicate a variety of potential issues, including cervical lesions or even endometrial carcinoma, and requires a thorough evaluation to determine the underlying cause.

Colposcopy allows for direct visualization of the cervix and any lesions, while endometrial sampling is essential for assessing the endometrial lining for potential abnormalities that could be indicated by AGUS findings. This comprehensive approach is crucial because AGUS can sometimes signify serious pathologies.

Other options, while they have their places in cervical screening and management, do not provide the thorough investigation necessary in the presence of atypical glandular cells. HPV DNA testing alone would not address the potential risks associated with AGUS, such as ruling out cervical or endometrial cancers. A repeat Pap smear in 3 months does not sufficiently evaluate the significant concern raised by AGUS. Additionally, while colposcopy with endometrial curettage (ECC) is a valuable procedure, it does not confirm the need for a sampling of the endometrium, which is critical in this scenario of AGUS. Thus, the combination of colposcopy with endometrial