What is an indication for using Rho-GAM in a pregnant patient?

Rho-GAM, also known as Rh immunoglobulin, is indicated for use in situations where there is a risk of Rh isoimmunization. This typically occurs when an Rh-negative mother is carrying an Rh-positive infant. If the mother is Rh-negative and the fetal blood contains Rh positive antigens, her immune system may produce antibodies against these antigens, which can lead to complications in current and future pregnancies.

In the scenario where the mother is Rh negative and the infant is Rh positive, administering Rho-GAM helps prevent the mother from developing these antibodies, thereby protecting any future pregnancies from potential hemolytic disease of the newborn (HDN), which can result from the mother's immune response to Rh-positive blood.

Thus, in the presence of an Rh-positive infant, Rho-GAM serves as a preventative measure for both the mother and subsequent pregnancies. This aligns directly with the indication for its use in clinical practice.