What is a major risk factor for developing an ectopic pregnancy?

A major risk factor for developing an ectopic pregnancy is a history of salpingitis. Salpingitis, which refers to inflammation of the fallopian tubes, is often caused by sexually transmitted infections, such as chlamydia or gonorrhea. The inflammation can lead to scarring and damage to the fallopian tubes, which increases the risk of an egg implanting outside the uterus, commonly in the fallopian tube itself.

Women with prior salpingitis often face altered tubal anatomy and motility, which can prevent the normal transit of the fertilized egg to the uterine cavity, resulting in an ectopic pregnancy. Therefore, a history of salpingitis is a significant factor in the development of ectopic pregnancies, distinguishing it from other potential risk factors that do not have as strong a connection to ectopic implantation.