In which of the following maternal-fetal blood type pairings should the mother receive Rho-GAM?

RhoGAM is a medication used to prevent Rh sensitization in Rh-negative mothers, particularly when there is a risk of mixing maternal and fetal blood, such as during pregnancy or delivery. It is specifically indicated when there is a mismatch between the Rh factor of the mother and the infant.

In the case of an AB negative mother, RhoGAM is necessary when there is a potential for the mother to be exposed to Rh-positive blood cells, which would occur if the infant is Rh-positive. The risk arises during events like delivery, miscarriage, or any situation where fetal blood may enter maternal circulation. Since the AB negative mother can have an Rh-positive fetus (if the father is Rh-positive), the administration of RhoGAM helps to prevent the mother from developing antibodies against the Rh factor, which can lead to complications in current or future pregnancies.

In contrast, scenarios like an A positive mother with an O negative infant do not require RhoGAM because the mother's blood type (Rh-positive) does not pose a risk of sensitization to Rh-negative fetal blood. Similarly, an A negative mother with an O negative infant does not require RhoGAM as there is no Rh-positive blood to sensitization concern. Lastly, for an AB