In which condition would you expect to find low estradiol alongside high FSH and LH levels?

During menopause, the ovaries significantly decrease their production of estradiol due to the depletion of ovarian follicles. This reduction in estradiol causes negative feedback on the hypothalamic-pituitary axis to diminish. As a result, levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) increase. The high levels of FSH and LH seen in menopause are a response to the diminished estrogen levels, indicating that the body is attempting to stimulate the ovaries in the absence of functional follicles.

This hormonal profile of low estradiol paired with high FSH and LH is characteristic of menopause and reflects the transition where the ovaries no longer respond effectively to gonadotropins. In contrast, other conditions, such as pregnancy, puberty, and the follicular phase of menstruation, involve distinct hormonal balances that do not match this pattern, as they typically showcase either normal or elevated levels of estradiol alongside varying levels of FSH and LH.